Health Psychology Research / HPR / Online First / DOI: 10.14440/hpr.0092
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REVIEW

The Impact of Exercise and the Potential Role of Exerkine Irisin on Sleep Quality: A Review

Klaudia Pawlik1 ,  Daniel Pomaski1 ,  Patrizia Pignataro2*
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1 Department of Interdisciplinary Medicine (DIM), School of Medicine, University of Bari, Bari 70121, Italy
2 Department of Translational Biomedicine and Neuroscience (DiBraiN), School of Medicine, University of Bari, Bari 70121, Italy
HPR, e81240025 https://doi.org/10.14440/hpr.0092
Submitted: 23 April 2025 | Revised: 28 July 2025 | Accepted: 26 August 2025 | Published: 19 December 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Background

Physical activity has been shown to positively affect sleep performance and is increasingly acknowledged as an evidence-based, non-pharmacologic intervention for insomnia. Physically active individuals report better sleep quality, fewer sleep disorders, and reduced daytime fatigue and sleepiness.

Objective

This review provides an overview of different physical therapies to improve sleep quality in patients with insomnia. It seeks to understand whether irisin, a molecular mediator of exercise, may be involved in improving sleep quality. This article examines the documented impact of exercise on sleep quality and the possible involvement of myokine irisin.

Conclusion

Based on the literature reviewed, exercise appears to be a promising non-pharmacological option for treating insomnia and improving sleep quality in adults. Overall, current data indicate that irisin, produced during physical activity, may be one of the molecular mediators involved in this process. However, further studies are needed to better clarify its specific regulatory role on sleep.

Keywords
Sleep quality
Insomnia
Physical activity
Irisin
Funding
This work was supported by funding to Giancarlo Logroscino from Regione Puglia for “Tecnopolo per la Medicina di Precisione”, D.G.R. n. 2117 of 21.11.2018 (CUPB84I18000540002).
Conflict of interest
The authors declare no conflicts of interest.
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Health Psychology Research, Electronic ISSN: 2420-8124 Published by Health Psychology Research
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